Vol. 7, Special Issue 2 (2025)

The primary objective of this investigation is to create herbal hand sanitizers using alcohol. The objective is to use Psidium guajava leaf extract to make and evaluate a herbal hand sanitizer. Its effectiveness demonstrates the advantages of using herbal hand sanitizer. Alcohol-based herbal hand sanitizers have the benefit of having no negative side effects. Natural herbal hand sanitizers are economical, efficient, and safe for the environment. By using hand sanitizer, adverse effects, including dermatitis, itching, and irritation, can be avoided. Active substances with antibacterial, anti-inflammatory, and antimicrobial qualities include flavonoids, tannins, and phenolics found in guava leaves. The biological properties of guava leaf extracts, such as their anticancer, antidiabetic, antioxidant, antidiarrheal, antibacterial, lipid-lowering, and hepatoprotective properties, have been investigated. The dispersion method was used to formulate the sanitizer. Glycerine, Carbopol 940, guava leaf extract, and ethyl alcohol were among the excipients utilized. Physical testing was conducted, such as homogeneity, spreadability, adhesiveness, pH, organoleptic (shape, smell, and color), and product irritation tests. The formulations had pH values between 5 and 6. A hand sanitizer made with guava leaf extract offers a pleasant scent and a more skin-friendly, eco-friendly alternative to alcohol-based synthetic sanitizers. Its lack of harmful chemicals like TEA and parabens makes it a safe and natural option for effective hand hygiene.