Vol. 7, Issue 1, Part C (2025)

Adiponectin is a protein hormone secreted predominantly by adipocytes (fat cells). It plays a crucial role in regulating glucose levels, lipid metabolism, and insulin sensitivity. It has been studied for its association with metabolic syndrome components and insulin resistance. The research involved 120 individuals diagnosed with Metabolic Syndrome, comprising 55 males and 65 females, and a control group of 40 males and 40 females ages 18 to 78. We aim to evaluate the adiponectin/HOMA-IR ratio as a reliable biomarker of metabolic syndrome in the Iraq/Basra population. The highest proportion of patients with MetS and controls were from 41 to 50 years of age. Hypertension was present in 74.2% of patients with MetS, and DM was present in 68.3% of patients with MetS. The parameter analysis showed that fasting blood sugar (FBS), total cholesterol, triglyceride levels, VLDL levels, High-sensitivity C-reactive protein (hs-CRP), and HOMA-IR levels were significantly higher (p≤0.001). Significantly lower (p≤0.001) in HDL-C, Adiponectin, and Adiponectin/HOMA-IR ratio levels in Metabolic Syndrome patients compared to the control subjects. The adiponectin/HOMA-IR ratio had a significant inverse correlation weak with WC, SBP, DBP, FBS, TG, and VLDL, and a strong correlation with insulin and HOMA-IR. Metabolic syndrome is a common health issue that increases the risk for several serious illnesses, such as Type 2 Diabetes Miletus (DM), Hypertension (HT), and coronary artery disease (CAD). Patients with MetS had significantly decreased adiponectin/HOMA-IR ratio, correlated with various components of MetS. The adiponectin/HOMA-IR ratio could serve as a simple, noninvasive, and cost-effective tool to aid healthcare providers in diagnosing and managing metabolic syndrome.