Vol. 6, Issue 2, Part A (2024)

The use of plants for the creation of nanoparticles has emerged as a promising subject, particularly with regards to silver nanoparticles (AgNPs) which have garnered significant attention due to their environmentally benign characteristics and wide range of biomedical applications. This study investigates the process of creating silver nanoparticles using extracts derived from the plants Cassia fistula and Terminalia chebula through a method known as green synthesis. The biosynthesis process utilises the phytochemicals included in these plant extracts, providing a sustainable, cost-effective, and easily expandable alternative to traditional chemical approaches. The synthesised silver nanoparticles (AgNPs) were analysed using UV-Vis spectroscopy, which verified their creation by observing different absorption peaks at 500 nm and 400 nm for T. chebula and C. fistula, respectively. Additional examination using FTIR and Zetasizer methods yielded valuable information regarding the functional groups and stability of the nanoparticles. The antimicrobial effectiveness was assessed against Gram-negative E. coli and Gram-positive S. aureus, demonstrating notable antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 4.8 to 5.3 μg/mL. The study also emphasised the promise of AgNPs in accurate drug delivery systems, wound healing, and cancer treatment, emphasising their adaptability in biomedical research. This research adds to the existing knowledge in the fields of nanotechnology and biomedicine, highlighting the potential of AgNPs synthesised using environmentally friendly methods to address current healthcare concerns.