Vol. 6, Issue 2, Part A (2024)

The term diabetes defines a group of chronic metabolic disorders characterized by high blood sugar (Hyperglycemia) in the absence of treatment, and occurs as a result of a defect in the secretion of the hormone insulin (Insulin), its function, or both. Or as a result of metabolic disorders of carbohydrates, fats, and proteins (1). Diabetes is one of the most common chronic conditions with multiple devastating complications for the body's systems. Diabetes is among the top ten causes of death in adults (2). Glucose is the vital element of the body that provides the body with the necessary energy. Glucose enters the cells through the hormone insulin, which acts as a main key for glucose to enter the cells, which is secreted from the beta cells in the pancreas. If there is an imbalance, such as in diabetes, glucose will accumulate in the bloodstream and be excreted through the urine (3). The current study was conducted on the effect of the OGG1 enzyme and knowing its level in the serum of people suffering from type 2 diabetes. (64) blood samples were obtained from people with type 2 diabetes whose ages ranged between (26-80) years. Both genders (35 males - 29 females), where samples were collected from Tikrit Teaching Hospital and their condition was diagnosed by specialized doctors. As for the control group, samples were collected from healthy people through routine examinations and blood donors in the hospital, where the number of samples for the control group was (36) A sample of people aged between (30-75) years of both sexes. The study also included finding a correlation between the OGG1 enzyme and some biochemical variables in patients with diabetes.