Vol. 6, Issue 1, Part A (2024)

We know that there are certain plants that help us to cure ailments; one such crucial plant is Gloriosa superba L. which helps to cure various diseases of the human body. One of the main causes of death for the vast majority of people worldwide is colon cancer, a pathologic condition caused by aberrant cell development. Around the world, Colon cancer is a serious health issue. Due to the stage of the malignancy, adverse effects, and altered bio-distribution, there are only a limited number of treatments such surgery, chemotherapy, radiation, and anticancer medications available, this treatment have high risk factor and high cost. Peptides taken from natural sources have come to be thought of as a possible therapeutic. Gloriosa superba L. has a long history of usage in traditional medicine, notably for anti-cancer, tumours, kidney issues, haemorrhoids, and wounds. Gloriosa superba L. contain colchicine, flavonoid and some other alkaloid which showed anti-cancer property. However, the aim of this study is an investigation of anti-colon cancer activity from some parts of Gloriosa superba plant which regulates p53, NF-κB of colon cancer cells (SW620)