Vol. 4, Issue 1, Part A (2022)

The most common endocrine condition, polycystic ovary syndrome (PCOS), influences 5 to 10% of all ladies in the conceptive age bunch. The objective of the ongoing review was to analyze the connection among PCOS and the Plasminogen Activator Inhibitor (PAI-1) 4G/5G polymorphism (rs1799889) in South Indian populaces. The goal of the current study is to thoroughly investigate potential genetic relationships and clinical implications in relation to polycystic ovary syndrome (PCOS). In order to better understand the underlying genetics of PCOS, this study aims to clarify the relationships between polymorphic variations of the PAI (4G/5G) gene (rs1799889) and a variety of clinical, biochemical, and hormonal markers. Two crucial research goals drive how the study develops. As a result, the findings of this paper have the potential to promote improvements in PCOS diagnosis, comprehension, and management, strengthening our understanding of the complex genetic and clinical web that creates this condition.